PubMed journal article [Idiopathic pulmonary hemosiderosis were found in PRIME PubMed. Download Source. Revista chilena de pediatrĂ­a pg PubMed journal article [Idiopathic pulmonary hemosiderosis: review of literature and case report were found in La Pediatria Sep 30 pg Revista Cubana de PediatrĂ­a Idiopathic pulmonary hemosiderosis is those processes characterized by anomalous depots of hemosiderin in the pulmonary.

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The patient is currently asymptomatic.

Idiopathic pulmonary hemosiderosis treated with azathioprine in a child

To improve our services and products, we use “cookies” own or third parties authorized to show advertising related to client preferences through the analyses of navigation customer behavior. Long-term prednisone and azathioprine treatment of a patient with idiopathic pulmonary hemosiderosis. Anemia might be the only manifestation of PH, preceding any other symptom and sign by several months.

SRJ is a prestige metric based on the idea that not all citations are the same. Vitamin B 12 and folic acid were within normal range and the bone marrow smear was compatible with sideropenia. Subscribe to our Newsletter. The chest radiograph showed a diffuse bilateral opacity with ill-defined edges, with a predominantly central location Figure 1suggestive of alveolar hemorrhage. Long-term outcome of idiopathic pulmonary hemosiderosis in children.

Gastrointestinal bleeding was ruled out after negative extensive etiological investigation. Open in a separate window. In this situation, therapy is often started at the stage in which pulmonary fibrosis has already developed, with a higher risk pediattia complications and worse prognosis.

Contudo, o acompanhamento da paciente por quatro anos afastou estas possibilidades, bem como a possibilidade de colagenoses e vasculites. Idiopathic pulmonary hemosiderosis is a potentially fatal disease that results from episodes of alveolar hemorrhage of unknown origin. Upper and hemisiderosis gastrointestinal hemosiderrosis with biopsies were performed and no hemorrhagic lesion was found, and the mucosa was macroscopically and histologically normal. After starting hemoziderosis treatment there was a progressive increase in Hb level and improvement of radiological abnormalities.


Are you a health professional able to prescribe or dispense drugs? J Pediatr Rio J. There are several known causes of diffuse alveolar hemorrhage vasculitides, connective tissue disorders, Heiner’s syndrome, cardiovascular diseases, among others. Treatment of idiopathic pulmonary hemosiderosis with inhaled flunisolide. The child is currently asymptomatic, with Hb levels between For this reason, he was not submitted to an upper esophagogastroduodenoscospy, as previously planned.

CiteScore measures average citations received per document published. Bronchoalveolar lavage fluid showing numerous hemosiderin-laden macrophages stained positive with Perls. No dia seguinte, mantinha-se grave, com piora do hemograma Hct: He was initiated on corticosteroid therapy, later associated to an immunosuppressive agent, with subsequent correction of anemia and of the radiological pattern.

There were no morphologic abnormalities or changes of hemosideross respiratory mucosa, and the cytological exam of the bronchoalveolar lavage showed Idiopathic pulmonary hemosiderosis in adults: Diffuse alveolar hemorrhage is caused by loss of integrity of the basement membrane hemosideroeis pulmonary capillaries, with consequent leakage of uemosiderosis into the alveolar space. Antineutrophil cytoplasmic antibodies ANCA in idiopathic pulmonary pediattia. Show all Show less.

To confirm alveolar hemorrhage, a fibrobronchoscopy was performed.


Budesonide inhalation to treat idiopathic pulmonary haemosiderosis. Although hemodiderosis do not make the definitive diagnosis of alveolar hemorrhage, chest radiography and CT scan may present suggestive but not specific aspects of hemorrhage, additionally contributing to the exclusion of other conditions.

A 4 year-old boy with a epdiatria history of recurrent wheezing, with no criteria of severity and no associated manifestations, was observed hemosiderosiz an emergency department for fever, vomiting and prostration. Eur J Med Res. How to cite this article. Idiopathic PH has been associated with celiac disease and, therefore, this condition should be excluded in these patients.


As an outpatient, he received weekly intravenous iron therapy and investigation of anemia was continued. Idiopathic pulmonary hemosiderosis – a diagnostic challenge. A pulmonary computerized tomography CT scan Figure 3 showed diffuse ground-glass attenuation in both lungs with no zonal predilection, some dispersed areas of lower density, and several scattered micronodules.

The clinical suspicion of alveolar hemorrhage was raised by the lack of response to iron therapy, with a progressive decrease in Hb levels and after extensive investigation of other potential sources of bleeding. You can change the settings or obtain more information by clicking here. However, the latter may also present acutely with massive and potentially fatal hemoptysis. J Clin Case Rep.

Severe iron-deficiency anemia as initial manifestation of pulmonary hemosiderosis in a child

Si continua navegando, consideramos que acepta su uso. He had no macroscopic blood loss, either from gastrointestinal or urinary tract. Severe respiratory distress in a child with pulmonary idiopathic hemosiderosis initially presenting with iron-deficiency anemia. Journal List Einstein Sao Paulo v. Pulmonary haemosiderosis in infants and children.

Iron-deficiency anemia is the most frequent hematologic disease in pediatrics. Diffuse bilateral opacity with ill-defined edges, with a predominantly central location. Acute respiratory insufficiency as debut of idiopathic pulmonary hemosiderosis in an infant. Five days after being discharged, he was seen again for fever, asthenia, coryza, and productive cough.

Favourable response to azathioprine. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.